PanCancer Analysis of Whole Genomes
Welcome to the PCAWG-Scout. This portal will help explore the data produced by the PCAWG project. It’s organized as a collection of reports centered around entities and lists of entities: donors, cohorts, genes, etc. These reports are computed on-demand and cached, and some even take parameters. Please consult the help page for more information.
You may also find tips on some parts of the site with additional information. These tips are green dots with a question mark inside appear at the top right part of a page section, and are revealed when hovering over that section; look, there is one down there!
You can start by checking out some of the cohorts bellow or by searching for a gene of interest in the search area above.
From this template you can access available cohorts, which are sets of donors grouped by certain histological criteria. The main organization is based on cohort abbreviations; these cohorts group tumors with the same main histological type but which could have been provided from different sequencing facilities. The project has provided official identifying colors that are used across the site. They have also been the subject of analysis of different working groups; for instance you will find driver calls. The second option are the Meta cohorts which group donors more generally, such as carcinomas or lymphomas; these have also been examined for driver call. Finally there are cohorts made around all four histology tiers and the tumor histological type; for these you may still run some of the driver prediction methods available in this site, but note that these are not as reliable as the official driver prediction calls made by the project.
There are certain tumors that contain very large numbers of mutations, called hyper-mutated, and which might negatively affect certain analyses. PCAWG-Scout provides alternative cohorts without hyper-mutators accessible through the NH links.